Cancer Metabolism Therapy with Rafael Pharmaceuticals

To Save A Life Is To Save A Universe

Developing innovative cancer therapies that will transform the way we treat patients.

Cancer Metabolism

Cancer Metabolism

A breakthrough approach to treating some of the most intractable forms of cancer

Breakthrough Cancer Therapies

Breakthrough Therapies

Rafael's proprietary AMD platform has produced a robust pipeline of breakthrough cancer therapies


To develop highly selective, well-tolerated, and highly effective anti-cancer agents, by selectively targeting cancer metabolism by inhibiting pro-cancer cells while preserving and stimulating anti-cancer immune system cells. Our immediate goal is to improve the quality of life of patients with pancreatic cancer, which is the deadliest cancer worldwide and has limited treatment options.


We aspire to be a high growth, fully integrated cancer metabolism therapeutics leader focused on improving and extending the lives of patients.

CPI-613® (devimistat)

Rafael Pharmaceutical’s first-in-class clinical lead compound, CPI-613® (devimistat), targets enzymes that are involved in cancer cell energy metabolism and are located in the mitochondria of cancer cells. CPI-613® is being evaluated in multiple Phase I, I/II, II, and III clinical studies as a single agent, as well as in combination with standard drug therapies, in patients diagnosed with advanced solid tumors or blood cancers.

The U.S. Food and Drug Administration (FDA) has given Rafael approval to initiate pivotal clinical trials in pancreatic cancer and acute myeloid leukemia (AML), and has designated CPI-613® as an orphan drug for the treatment of Pancreatic Cancer, AML, Myelodysplastic Syndromes (MDS), Peripheral T-Cell Lymphoma, Burkitt’s lymphoma and Soft Tissue Sarcoma. The EMA has granted orphan drug designation to CPI-613® for Pancreatic Cancer and AML. Also the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to CPI-613® for Pancreatic Cancer and AML.

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World Class Team

Innovation in oncology drug development requires a deep well of scientific, medical and business expertise, and we have assembled an unparalleled team of directors and advisors who are working with Rafael to revolutionize anticancer treatment.

Our Board of Directors and Scientific & Medical Advisory Boards are drawn from the highest echelons of oncology and hematology researchers and physicians, and include seasoned managers from the biotech and pharmaceutical sectors.

Pancreatic Cancer Action Network

Rafael is a proud sponsor of the Pancreatic Cancer Action Network

Founded in 1999, the Pancreatic Cancer Action Network (PanCAN) is dedicated to fighting one of the world’s toughest cancers. In their urgent mission to save lives, PanCAN attacks pancreatic cancer on all fronts: research, clinical initiatives, patient services, and advocacy.

Rafael Pharmaceuticals has sponsored PanCAN PurpleStride Walks to end Pancreatic Cancer across the country.

Purple Stride - Pancreatic Cancer Action Network Rafael Pharmaceuticals - Sponsors of Pancreatic Cancer Action Network